Ricerca: “Eupatorium perfoliatum” previene e allevia la patogenesi polmonare indotta dalla proteina spike SARS-CoV-2 regolando la risposta infiammatoria e l’apoptosi

Pubblicato il in News

Lavoro pubblicato sulla rivista “Diseases”. 2025 Jan 30;13(2):36.
doi: 10.3390/diseases13020036.

Ultradiluted Eupatorium perfoliatum Prevents and Alleviates SARS-CoV-2 Spike Protein-Induced Lung Pathogenesis by Regulating Inflammatory Response and Apoptosis

✅ Sfondo/obiettivi:
SARS-CoV-2 provoca stress ossidativo acuto nei polmoni tramite citochine, mediatori infiammatori e fattori apoptotici, che potrebbero causare lesioni alveolari seguite da grave sindrome respiratoria durante l’infezione da COVID-19.

La mancanza di particolari antivirali per SARS-CoV-2 ha aperto nuove strade di medicina complementare e non convenzionale come potenziale rimedio.

Lo studio attuale ha esplorato il ruolo meccanicistico della formulazione ultra-diluita di Eupatorium perfoliatum (UDE) contro lo stress ossidativo mediato dalla proteina S ricombinante SARS-CoV-2 e la mitocondropatia.

✅ Metodi:
La linea cellulare e i topi BALB/c sono stati utilizzati per segnalare che la proteina SARS-CoV-2 S ha causato una risposta infiammatoria e la successiva tempesta di citochine attraverso la via NF-κB nei polmoni insieme a danni ossidativi. L’esame morfologico è stato eseguito utilizzando la colorazione DAPI e l’istologia rispettivamente per le cellule trattate e i tessuti polmonari degli animali.

Eupatorium perfoliatum

Il meccanismo d’azione molecolare di UDE è stato studiato attraverso qRT-PCR per le espressioni genetiche di varie citochine, mediatori infiammatori e apoptotici; ELISA, immunofluorescenza, immunoistochimica e Western blot per l’espressione traslazionale delle stesse molecole testate per le espressioni genetiche; e saggi biochimici per vari enzimi e ROS.

✅ Risultati:
Il trattamento UDE (formulazione ultra-diluita di Eupatorium) ha soppresso l’infiltrazione delle cellule infiammatorie e lo stress ossidativo a livello tissutale e ha salvaguardato l’integrità mitocondriale dal danno ossidativo mediato dai radicali liberi.

Inoltre, l’UDE (formulazione ultradiluita di Eupatorium) ha svolto un ruolo diretto nel ripristino dell’omeostasi redox cellulare e nella riduzione della risposta infiammatoria sopprimendo NF-κB, IL-1β, IL-18, espressione della caspasi-1 e formazione di ROS. Inoltre, è stato proposto un meccanismo d’azione plausibile di UDE (formulazione ultra-diluita di Eupatorium) contro il danno indotto dalla proteina S.

✅ Conclusioni:
Questo studio ha descritto un nuovo approccio terapeutico contro l’iperinfiammazione mediata dalla proteina S, l’apoptosi e il danno ossidativo.

Pertanto, la formulazione ultradiluita di Eupatorium (UDE), può essere considerato come un’alternativa prospettica per combattere le conseguenze potenzialmente letali dell’infezione da SARS-CoV-2.

 

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Comunicazione a cura di:
Centro di Salute Globale SIMOH
Scuola Italiana di Medicina Omeopatica Hahnemanniana
Via Giovanni Miani, 8 – 00154 Roma
www.omeopatiasimoh.org – info@omeopatiasimoh.net

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